Mission: Disease Free India
The Miracle Product : Gama Oryzanol
–By Prof. Vijay Agrawal
For the last two years the entire world is facing consequences of Covid-19 pandemic and the only remedy for this pandemic, suggested, is the immune system. Now a days everybody is talking about how to improve the immune system of our body. Unfortunately the exact mechanism of Covid-19 virus is not known till date. A lot of researches are being carried out in this regard. The virus is changing its face which is called mutation. The second wave has created further problems among us.
For the last one year it is being said that the people should keep social distancing, use sanitizer and wash their hands frequently. This will help in controlling the pandemic. The worst part of the Corona virus is that it damages the vital organ “lungs” of human being, the lowering of oxygen level and some times it may cause death.
In this pandemic natural product of rice bran which is known as Gamma Oryzanol is being studied which is suppose to be very effective in the treatment/ controlling of many diseases including the adverse effect of Corona virus. In fact Gama Oryzanol is a substance that is taken out of rice bran. In various countries people use it as medicine.
Review of literature reveals that Isolation, extraction, and purification of Gamma Oryzanol (GO) was first reported in the mid-1950s. It has been sold in Japan as a medicine since 1962,. In the beginning to treat anxiety and later in menopause.
Japanese dieticians used Gamma Oryzanol and rice bran oil therapy to manage elevated cholesterol and triglyceride levels since the late 1980s. Rice bran oil and extracts are considered to be very safe.
It Controls Cholesterol
Most research shows that taking GO by orally decreases total cholesterol, “bad” low-density lipoprotein (LDL) cholesterol, and triglycerides (blood fats) people with high cholesterol. The effects of GO on “good” high-density lipoprotein (HDL) cholesterol is also encouraging. Rice bran oil with gamma oryzanol also lowers LDL cholesterol.
The gamma oryzanol has been termed miraculous substance because of its so many healing properties. Few Brazilian scientists in association with A FILHO have found that gamma-oryzanol acts as a potential lipid-lowering agent, reducing triglycerides and total cholesterol in dyslipidemia-induced models.
Few years back Igor Otavio Minatel et al. Found that in addition to its antioxidant activity, gama oryzanol is often associated with cholesterol-lowering, anti-inflammatory, anti-cancer and anti-diabetic effects. Which further supported the earlier study.
In recent years, the usefulness of GO has been studied for the treatment of metabolic diseases, as it acts to ameliorate insulin activity, cholesterol metabolism, and associated chronic inflammation.
Earlier studies have shown the direct action of Oryzonal when down regulating the expression of genes that encode proteins related to adiposity , enhancer binding proteins , inflammatory responses (nuclear factor kappa-B and metabolic syndrome.
It is likely that this wide range of beneficial activities results from a complex network of interactions and signals triggered, and/or inhibited by its antioxidant properties.
The significance of GO in metabolic disorders, which feature remarkable oxidative imbalance, such as impaired glucose metabolism, obesity, and inflammation has been reported in different studies.
This natural compound has been found to act as immunity booster , use of which is very much recommended during Corona-19 pandemic by experts.
The scientists have found that if persons are taking gama oryzanol much before the infection of corona virus occurs, the cytokine storm will not cause much damage to the person and his life will be saved.
It is worth mentioning that Cytokine storm is an umbrella term encompassing several disorders of immune dysregulation and multiorgan dysfunction that can lead to multiorgan failure if inadequately treated.
I would like to reproduce a news paper report quoting Dr. Neha Gupta, Infectious Diseases specialist, Medanta , New Delhi – Gamma-oryzanol has anti-inflammatory and antioxidant properties and due to which it has the potential to be helpful in preventing negative clinical outcomes in such patients who have inflammatory tendencies.
She further added that “In COVID-19, patients might develop a hyper inflammatory condition and the cytokine storm syndrome, which can lead to organ dysfunctions and failure, and even, death.”
This statement got endorsement of Dr. S P Byotra, Chairman of Department of Medicine, Sir Ganga Ram Hospital, New Delhi who also says that the consumption of gama oryzanol is helpful in reducing inflammation in body and if by chance that person catches Covid-19, complications in such person who is already using anti-inflammatory and antioxidant compound i.e. gamma oryzanol will be very less severe and the chance of cytokine storm will be prevented by the body’s own immune system.
A recent study from Tulane University on 287 hospitalized Covid-19 patients found that metabolic syndrome itself substantially increased the risks of ICU admission, ventilation, and death.
Studies have also shown that the gamma-oryzanol has a positive action in the treatment of some obesity-related comorbidities and attenuation of proinflammatory cytokines.
Super anti oxidant
It is known that Anti oxidants are compounds which inhibits production of free radicals in our body. Free radicals are molecules produced when body breaks down food or when people are exposed to tobacco smoke or radiation. The latest antioxidant which is produced for the first time in India is gamma oryzanol, which is very quickly gaining popularity as a super antioxidant.
Study reveals that gama oryzanol has four times more potent than Vitamine E which is commonly known for its antioxidant property. Thr Ferulic and p-coumaric acids are the phenolic components which are responsible for inhibition of infection and inflammation. Therefore, this compound has been treated as super anti oxidant.
People in the most countries are suffering because of increase in bad Cholestrol . This is the main cause of heart disease because it effects narrowing of the veins causing high blodd pressure, hyper tension.
Most researches shows that taking gamma oryzanol orally decreases total cholesterol, “bad” low-density lipoprotein (LDL) cholesterol, and blood fats called triglycerides .
Taking gamma oryzanol along with vitamin E, omega-3 fatty acids, and niacin by mouth for 4 months also seems to reduce LDL cholesterol in people with high cholesterol.
It has been found that the gamma oryzanol inhibits production of low density lipo protein cholesterol and converts it into bile acid which goes out of body. It reduces the production of serum cholesterol and absorption of food cholesterol increases the HDL which is boon for heart.
Dr. Swapna Chaturvedi, senior dietician, Department of Dietetics, AIIMS,New Delhi says that Gamma oryzanol helps lower cholesterol because it helps decrease cholesterol absorption and increase cholesterol elimination. It is also known to boost metabolic rate and may help with weight loss, curing obesity related problems.
As gamma oryzanol is found to be effective in controlling high cholesterol level in the body, it is registered in Japan and the US as a natural medicine to treat hyperlipidemia/ dyslipidaemia (elevated cholesterol levels/unhealthy cholesterol levels.
Helps in preventing heart attacks
Dr. Praveen Chandra, Head of Department, Interventional Cardiology, Medanta, The Medicity in Gurugram has very keenly observed the impact of gama oryzanol on heart. He says that it also helps in preventing heart attack by preventing platelet aggregation, a system where platelets blood gets stuck together and form clots that block arteries,
It controls cancer!
Gamma oryzanol also helps to inhibit different cancers in the body and builds immunity to fight cancer cells. Scientific report available show that it helps in regressing the prostate cancer cells. Gamma oryzanol is basically activator of NK cells which gives the cancer cells a check. It not only works through NK cells but also inhibits angiogenesis. It means it cuts the supply for the cancer cells to grow and increases your body’s own immunity to gather the strength to kill cancers.
Dr. Rahul Bhargava, Director, Institute of Blood Disorder and BMT, Fortis Hospital, New Delhi in a statement appeared in newspapers has said that Many of the antioxidants have proven beneficial in inhibiting the cancers at various stages. Gamma oryzanol has been found out to be effective antioxidant which comes from rice bran and helps in preventing cancer if taken for a long period.
Furthermore, the recent work by Kim has shown that gamma-oryzanol significantly reduced the tumour mass in mice inoculated with CT-26 colon cancer. The researchers have suggested that low dose of gamma oryzanol is very safe for cancer patents. It is very much effective in the treatment of tumour and skin cancer both.
In most countries the sports person consume gamma oryzanol for gaining strength. The experts mentioned that gamma oryzanol is also used in increasing testosterone and human growth hormone levels, as well as improving strength during resistance exercise training.
Effective in the treatment of Diabetes
The researches carried out on diabetes have revealed that the insulin doses have been reduced gradually after taking gamma oryzanol capsules. This study evaluated the effects of gamma-oryzanol on insulin resistance and lipid metabolism in Wistar rats with type 2 diabetes .
A world renowned group of scientists Kozuka et al have reported that gamma-oryzanol directly ameliorates ER stress-induced β-cell dysfunction and subsequent apoptosis, highlighting usefulness of gamma-oryzanol for the treatment of diabetes mellitus.
It is interesting to note that about 70 countries are using this product for the last twenty years.
Gamma Oryzanol and Isha Vashishth
Ms Isha Vashisht a famous dieticians and working on the mission DISEASE FREE INDIA is delivering talks on web how the gamma oryzanol has been accepted by the medical fraternity not in India but also in ter entire World.
She explains that why we should boost our immune system and also gives the glimpses of miracle effect of this natural compounds which helps in the treatment of at least twelve diseases including diabetes, ulcer, depression, hypertension etc.
She said that the Government of India in gadget notification has given a name to this product as neutraceutical. It refers to a product derived from food sources with extra health benefits in addition to the basic nutritional value found in foods.
She says that about 80 Crore population in India is suffering from diseases and consuming chemical compounds as drugs. They have side effects also. About 40 million people suffer with thyroid ailment. The natural product gama oryzanol produced in India has a purity of more than 103% which has been certified by Japan, the country which initiated the use of this compound.
She suggests that if people regularly take 3 capsules of 100 mg each their immune system will certainly protect them from deadly diseases. The cost of this product is one tenth as compared to European countries thus making it affordable for common people to take benefit of this product.
In my opinion the natural substances are always better than chemically synthesised drugs. Therefore, the gama oryzanol has no serious side effects reported so far.
This miracle product has a capacity to save the humanity from deadly diseases aprt from reducing the cost of being remain healthy. The saying ” एकोSहं बहुस्यामि ” is very much applicable for this miracle product gama oryzanol.
The author has prepared this review article on the basis of research papers, media reports and other noted works related to gama oryzanol available in website Google. The author expresses his thanks to Ms Isha Vashishth for educating him about the application of this product.
About the writer:
Prof. Vijay K Agarwal is Professor and Head, Department of Chemistry in APS University, Rewa. He is working in Computer Aided Drug Discovery, theoretical and medicinal chemistry for the last 40 years . He has published more than 200 research papers in National and International journals . He proposed a new topological index “Sadhana index” which is widely being used in modeling the drug activities and also very useful in predicting the properties of carbob nano tubes.
Email: [email protected]